Endocrine Abstracts

MC3-R expressed in the brain are well characterized however the role of MC3-R in the periphery is unclear. Recently, we described immunopositive staining for MC3-R in the testes of wild-type mice and reported that the testicular histology of the MC3-R null mouse was abnormal. The aims of this further work were to confirm that MC3-R is expressed in testes and determine if ACTH1–39 affects testicular steroidogenesis in vitro.RNA and ...

Melanocortin receptors (MCS, MC1–MC5) are GPCRs, activated with different affinities by the melanocortin peptides (α-, β-, γ-MSH and ACTH). They are widely distributed throughout the body displaying a multitude of actions however their role in reproductive physiology is unclear. Previously, we have shown a reduction of pituitary hormone content and abnormalities in testes morphology in male MC3 null mice. The aim ...